I recently completed a piece entitled "Orbs in the Grass" done completely in Blender 2.5 r28678. A simple piece which used the new Cloud Generator script to create the clouds and a couple particles systems for the grass, and although it isn't perfect it's pretty good for me. You can see my BlenderArtists thread on it here.
here. It is very effective with a tablet, which sadly I lack, but you can still do amazing things with it using just a mouse. Allthough I wouldn't call my art amazing, I still think it's pretty cool. This is based on a concept sketch I did one day. I can truthfully say, it looks a lot better in the colour that you can get with MyPaint!